Education and Training
Comparing SingLe- Vs Multi-Fraction Spine STereotActic Radiosurgery in Spinal Metastases
The goal of this study is to determine whether fractionated Stereotactic radiosurgery (SRS) for spine metastases is associated with improved local tumor control compared to single-fraction SRS. Patients will be randomized to treatment with spine SRS using either 22 Gy in 1 fraction or 28 Gy in 2 fractions.
Stanford is currently accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- radiation: Single-fraction spine SRS
- radiation: Multi-fraction spine SRS
Eligibility
Inclusion Criteria:
- Histologically, cytologically, or radiographically confirmed diagnosis of metastatic
cancer Age ≥ 18 years
- Patients who have cervical, thoracic, or lumbar spine metastasis that need treatment.
- Patients will have 1 to 3 separate spinal sites that require treatment.
- Each spinal site to be treated on trial will span 1-2 contiguous vertebral levels
- ECOG 0-2
- Negative serum or urine pregnancy test within 14 days prior to enrollment for women of
childbearing potential or who are not postmenopausal
- Women of childbearing potential and male participants who are sexually active must
agree to use a medically effective means of birth control
- Ability to understand and the willingness to sign (personally or by a legal authorized
representative) the written IRB approved informed consent document
Exclusion Criteria:
- Prior or planned radiation off study within or overlapping with study treatment site
- Inability to have either an MRI or a CT scan. Patients with pacemaker will be allowed
to undergo CT instead of MRI
- Pediatric patients (age <18 years old), pregnant women, and nursing patients will be
excluded
- Histology's of myeloma or lymphoma
- Patients with strength 1-3 (of 5), bladder incontinence, bowel incontinence, and/or
bladder retention that is associated with spinal site to be treated
- Prior surgery to spinal site intended to be treated with protocol SRS
- Excluded those with SINS 13-18
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Aniket Pratapneni
650-723-3110
I'm interested