Education and Training
Colorectal Cancer Screening in Cystic Fibrosis
This multi-center study will compare multi-target DNA and quantitative FIT stool-based testing to colonoscopy in individuals with Cystic Fibrosis (CF) undergoing colon cancer screening with colonoscopy. The primary endpoint is detection of any adenomas, including advanced adenomas and colorectal cancer (CRC).
Stanford is currently accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- procedure: Stool tests
Eligibility
Inclusion Criteria:
1. Adults with CF ages 18 - 75 years and due for a routine screening or surveillance
colonoscopy for colon cancer
2. Cystic Fibrosis diagnosis, defined by a sweat chloride test result ≥ 60 mmol/L (may be
of historic value), and/or documented CF-causing CFTR mutations and clinical features
of CF
3. Capable of understanding the purposes and risks of the study in English or Spanish and
willing to participate and sign informed consent
4. Referred for screening or surveillance colonoscopy for CRC (current standard of care)
and willing to undergo colonoscopy and stool testing
5. Able to access the Internet to complete self-administered surveys
Exclusion Criteria:
1. Any condition that, in the opinion of the site PI, introduces undue risk by
participating in this study
2. Incapable of understanding the purposes of the study or informed consent for any
reason
3. Pregnancy
4. Active inflammatory bowel disease as defined by a prior diagnosis of Crohn's Disease
or Ulcerative Colitis, based on both clinical and histopathologic findings and the
individual currently on medical therapy for Crohn's disease or Ulcerative Colitis.
5. Personal history of colon cancer diagnosis and treatment within 5 years of enrollment
6. Symptoms that merit colonoscopy for diagnostic purposes rather than as screening for
CRC
7. Known history of familial colon cancer syndrome that has been confirmed by previous
genetic testing
Ages Eligible for Study
18 Years - 75 Years
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Sukhada Mairal, PhD
I'm interested