Inclusion Criteria:

   - Patients ≥18 years of age with insulin-treated T1 or Type 2 diabetes mellitus (T2DM)
   admitted to general (non-intensive care) medical-surgical hospital service requiring
   inpatient insulin therapy.

Exclusion Criteria:

   - Patients admitted the ICU or anticipated to require ICU transfer

   - Anticipated length of hospital stay <48 hours.

   - Evidence of hyperglycemic crises (diabetic ketoacidosis or hyperosmolar hyperglycemic
   state) at enrollment

   - Severely impaired renal function (eGFR < 30 ml/min/1.73m2) or clinically significant
   liver failure

   - Severe anemia with hemoglobin <7 g/dL

   - Evidence of hemodynamic instability

   - Hypoxia (SpO2 <95% on supplemental oxygen)

   - Pre-admission or inpatient total daily insulin dose >100 units

   - Mental condition rendering the participant unable to consent or answer questionnaires

   - Pregnant or breast feeding at time of enrollment

   - Unable or unwilling to use rapid-acting insulin analogs (Humalog, Admelog, Novolog or
   Apidra) during the study

   - Use of hydroxyurea or high-dose ascorbic acid (>1g/day)

   - Coronavirus Disease 2019 (COVID-19) infection or person under investigation (PUI) on
   isolation precautions