Education and Training
A Study of Talquetamab in Participants With Relapsed or Refractory Multiple Myeloma
The purpose of this study is to evaluate the efficacy and safety of talquetamab in participants with relapsed or refractory multiple myeloma at the recommended Phase 2 dose(s) (RP2Ds) (Part 3).
Stanford is currently not accepting patients for this trial.
Intervention(s):
- drug: Talquetamab
Eligibility
Inclusion Criteria:
- Documented initial diagnosis of multiple myeloma according to international myeloma
working group (IMWG) diagnostic criteria
- Part 3: Measurable disease cohort A, cohort B, cohort C, and cohort D: multiple
myeloma must be measurable by central laboratory assessment
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2
- Women of childbearing potential must have a negative pregnancy test at screening and
prior to the first dose of study drug using a highly sensitive pregnancy test either
serum (beta human chorionic gonadotropin [hCG]) or urine
- Willing and able to adhere to the prohibitions and restrictions specified in this
protocol
Exclusion Criteria:
- Part 3 only: Cohort A and Cohort C only: exposed to a CAR-T or T cell redirection
therapy at any time. Cohort B and Cohort D: T cell redirection therapy within 3 months
- Toxicities from previous anticancer therapies should have resolved to baseline levels
or to Grade 1 or less except for alopecia or peripheral neuropathy
- Received a cumulative dose of corticosteroids equivalent to >= 140 milligram (mg) of
prednisone within the 14-day period before the first dose of study drug (does not
include pretreatment medication)
- Stroke or seizure within 6 months prior to signing the informed consent form (ICF)
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Kelly Chyan
650-625-8130
Not Recruiting