Key Inclusion Criteria:

   - Be at least 12 years of age and weigh at least 40 kg.

   - Have Grade 2 oligodendroglioma or astrocytoma per WHO 2016 criteria.

   - Have had at least 1 prior surgery for glioma (biopsy, sub-total resection, gross-total
   resection), with the most recent surgery having occurred at least 1 year (-1 month)
   and not more than 5 years (+3 months) before the date of randomization, and no other
   prior anticancer therapy, including chemotherapy and radiotherapy and not be in need
   of immediate chemotherapy or radiotherapy in the opinion of the Investigator.

   - Have confirmed IDH1 (IDH1 R132H/C/G/S/L mutation variants tested) or IDH2 (IDH2
   R172K/M/W/S/G mutation variants tested) gene mutation status disease by central
   laboratory testing during the Prescreening period and available 1p19q status by local
   testing (eg, fluorescence in situ hybridization [FISH], comparative genomic
   hybridization [CGH] array, sequencing) using an accredited laboratory.

   - Have MRI-evaluable, measurable, non-enhancing disease, as confirmed by the BIRC.

   - Have a Karnofsky Performance Scale (KPS) score (for participants ≥16 years of age) or
   Lansky Play Performance Scale (LPPS) score (for participants <16 years of age) of
   ≥80%.

Key Exclusion Criteria:

   - Have had any prior anticancer therapy other than surgery (biopsy, sub-total resection,
   gross-total resection) for treatment of glioma including systemic chemotherapy,
   radiotherapy, vaccines, small-molecules, IDH inhibitors, investigational agents, laser
   ablation, etc.

   - Have features assessed as high-risk by the Investigator, including brainstem
   involvement either as primary location or by tumor extension, clinically relevant
   functional or neurocognitive deficits due to the tumor in the opinion of the
   Investigator (deficits resulting from surgery are allowed), or uncontrolled seizures
   (defined as persistent seizures interfering with activities of daily life AND failed 3
   lines of antiepileptic drug regimens including at least 1 combination regimen).