Education and Training

Safety and Diagnostic Efficacy of Mangoral in Participants With Focal Liver Lesions and Reduced Kidney Function

The overall objective of this study is to evaluate the safety and diagnostic efficacy of Mangoral in liver MRI in participants with known or suspected focal liver lesions and severe renal impairment. The diagnostic efficacy of Mangoral will be assessed in terms of visualization of detected focal liver lesions in combined MRI (CMRI: combined Mangoral-enhanced and unenhanced MRI) compared to unenhanced MRI.

Stanford is currently not accepting patients for this trial.

Stanford Investigator(s):

Intervention(s):

  • drug: Mangoral

Eligibility


Inclusion Criteria:

   - Male and female participants 18 years and older.

   - Known or suspected focal liver lesions based on medical history and previous
   laboratory and/or imaging examinations.

   - Severe renal impairment (estimated glomerular filtration rate [eGFR] < 30 mL/min/1.73
   m^2) based on medical history and previous laboratory examinations, at least once,
   within the last 3 months prior to the Baseline Visit, or participants with an increase
   in serum creatinine ≥ 0.3 mg/dL within 48 hours or ≥ 50% within 7 days prior to the
   Baseline Visit.

Exclusion Criteria:

   - Participants with simple liver cysts only.

   - Any investigational drug or device within 6 weeks prior to the Baseline Visit.

   - Any magnetic resonance imaging (MRI) contrast media within 6 weeks prior to Baseline
   Visit or scheduled to receive any contrast medium before the last study visit.

   - Participants with severe hepatic impairment (according to Child-Pugh score C).

   - Participants scheduled for surgery before last study visit.

   - Participants with encephalopathy / neurodegenerative or acute neurological disorders.

   - Participants with hemochromatosis.

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Brittney Williams
650-736-3688
Not Recruiting