Inclusion Criteria:

   - Biopsy proven prostate adenocarcinoma.

   - Rising prostate-specific antigen (PSA) after definitive therapy with prostatectomy or
   radiation therapy (external beam or brachytherapy).

   a. Post radical prostatectomy (RP) - American Urological Association (AUA)
   recommendation.

   (i) PSA greater than 0.2 ng/mL measured after at least 6 weeks from radical
   prostatectomy.

(ii) Confirmatory persistent PSA greater than 0.2 ng/mL (total of two PSA measurements
greater than 0.2 ng/mL).

b. Post-radiation therapy ? American Society for Therapeutic Radiology and Oncology
(ASTRO)-Phoenix consensus definition.

(i) A rise of PSA measurement of 2 or more ng/mL over the nadir.

   - Able to provide written consent.

   - Karnofsky performance status of >= 50 (or Eastern Cooperative Oncology Group
   [ECOG]/World Health Organization [WHO] equivalent).

Exclusion Criteria:

   - Inability to lie still for the entire imaging time.

   - Inability to complete the needed investigational and standard-of-care imaging
   examinations due to other reasons (severe claustrophobia, radiation phobia, etc.).

   - Any additional medical condition, serious intercurrent illness, or other extenuating
   circumstance that, in the opinion of the Investigator, may significantly interfere
   with study compliance.

   - Known allergy, hypersensitivity, or intolerance to the investigational product or its
   excipients.

   - Metallic implants (contraindicated for magnetic resonance imaging [MRI]).