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Modulating Inhibitory Control Networks in Gambling Disorder With Theta Burst Stimulation

In this project the investigators propose a randomized double-blind placebo-controlled design in which 40 patients with GD will receive active or sham cTBS to the pre-SMA for 2 weeks. The investigators will combine TMS, multimodal structural and functional MRI and behavioral measures in order to identify circuit-level mechanisms of action and therapeutic targets (connectivity changes that explain clinical improvement) and assess the efficacy of TMS in modulating inhibitory control and symptom severity in this population.

Stanford is currently accepting patients for this trial.

Intervention(s):

  • device: Transcranial Magnetic stimulation

Eligibility


Inclusion Criteria:

   1. DSM-5 diagnosis of Gambling Disorder

   2. Age between 18 and 65 years

Exclusion Criteria:

   1. any additional current psychiatric comorbidity, except for nicotine addiction;

   2. a lifetime DSM-5 diagnosis of schizophrenia or other psychotic syndromes, substance
   dependence or substance abuse, including alcohol, bipolar I or II disorder, mental
   disorder due to a general medical condition;

   3. serious suicide risk;

   4. illness duration less than two years;

   5. hospitalization in the last 6 months;

   6. the inability to receive TMS because of metallic implants, or history of seizures
   (personal or family history of seizure in first degree relatives);

   7. any major medical disease;

   8. pregnancy or nursing of an infant;

   9. the inability or refusal to provide written informed consent.

Ages Eligible for Study

18 Years - 65 Years

Genders Eligible for Study

All

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Recruiting