Inclusion Criteria:

   1. Histologically confirmed large B-cell lymphoma, including the following types:

      1. DLBCL, not otherwise specified

      2. Primary mediastinal large B-cell lymphoma

      3. High-grade B-cell lymphoma

      4. DLBCL arising from follicular lymphoma (transformed follicular lymphoma, or TFL)

   2. Relapsed or refractory disease, defined as one or more of the following:

      1. No response to first-line therapy (primary refractory disease); subjects who are
      intolerant to first-line therapy chemotherapy are excluded OR

      2. No response or relapse to second or greater lines of therapy OR

      3. Relapsed after ASCT

   3. Subjects must have received adequate prior therapy including at a minimum:

      1. anti-CD20 monoclonal antibody unless investigator determines that tumor is CD20
      negative, and

      2. an anthracycline containing chemotherapy regimen;

   4. No evidence, suspicion, and/or history of central nervous system (CNS) involvement of
   lymphoma

   5. Age 18 or older

   6. Eastern cooperative oncology group (ECOG) performance status of 0 or 1

   7. Absolute neutrophil count ANC ≥1000/μL

   8. Platelet count ≥75,000/μL

   9. Absolute lymphocyte count ≥100/μL

10. Adequate renal, hepatic, pulmonary and cardiac function defined as:

      1. Creatinine clearance (as estimated by Cockcroft Gault) ≥ 60 mL/min

      2. Serum alanine aminotransferase/aspartate aminotransferase (ALT/AST) ≤2.5 upper
      limit of normal (ULN)

      3. Total bilirubin ≤1.5 mg/dL, except in subjects with Gilbert's syndrome.

      4. Cardiac ejection fraction ≥ 50% and no evidence of pericardial effusion within
      180 days provide the subject did not receive an anthracycline based treatment or
      experience a cardiac event or change in performance status

      5. No clinically significant pleural effusion

      6. Baseline oxygen saturation >92% on room air

11. Cohort 2 inclusion criteria: Subjects whose commercial manufacture of axicabtagene
   ciloleucel did not meet commercial release specification(s)

Exclusion Criteria:

   1. History of malignancy other than nonmelanoma skin cancer or carcinoma in situ (e.g.
   cervix, bladder, breast) or follicular lymphoma unless disease free for at least 3
   years

   2. History of allogeneic stem cell transplantation (SCT)

   3. Prior CD19 targeted therapy

   4. Prior chimeric antigen receptor therapy or other genetically modified T-cell therapy

   5. History of severe, immediate hypersensitivity reaction attributed to aminoglycosides

   6. Presence or suspicion of fungal, bacterial, viral, or other infection that is
   uncontrolled or requiring intravenous (IV) antimicrobials for management. Simple
   urinary tract infection (UTI) and uncomplicated bacterial pharyngitis are permitted if
   responding to active treatment and after consultation with the Kite Pharma Medical
   Monitor

   7. History of human immunodeficiency virus (HIV) infection or acute or chronic active
   hepatitis B or hepatitis C infection. Subjects with a history of hepatitis infection
   must have cleared their infection as determined by standard serological and genetic
   testing per current Infectious Diseases Society of America (IDSA) guidelines

   8. History or presence of primary CNS lymphoma and/or CNS disorder such as seizure
   disorder, cerebrovascular ischemia/hemorrhage, dementia, cerebellar disease, or any
   autoimmune disease with CNS involvement

   9. Cohort 2 exclusion criteria: Any medical condition that, deemed by the investigator,
   may interfere with assessment of safety or efficacy of study treatment