Education and Training
Study to Evaluate Immunological Response to PD-1 Inhibition in Squamous Cell Carcinoma of the Head and Neck (SCCHN)
This is a single-center cross-sectional imaging and correlative biomarker study in patients with Squamous Cell Carcinoma of the Head and Neck (SCCHN). Cohort 1 will be patients with unresectable or metastatic SCCHN cancer receiving standard of care (SOC) anti-PD-1 treatment and Cohort 2 will be neoadjuvant study participants who will receive one dose of anti-PD-1 treatment prior to tumor resection or radiation. Blood sampling and tissue biopsies will be collected from both cohorts and both cohorts will undergo two whole body PET(Positron Emission Tomography)/CT(Computed Tomography) imaging with [18F]F-AraG. First scan prior to initiating anti-PD-1 treatment and second scan post initiation of anti-PD-1 treatment in Cohort 1 and prior to tumor resection or radiation in Cohort 2
Stanford is currently not accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: [18F]F-AraG PET Scan, baseline + post anti-PD-1 therapy.
- drug: [18F]F-AraG PET Scan, baseline + post anti-PD-1 therapy.
Eligibility
Inclusion Criteria:
- Unresectable or metastatic SCCHN.
- Localized SCCHN.
- >18 years old.
- Willing and able to sign consent form.
- Have standard of care biopsy or resection planned or tumors amenable to serial
biopsies.
- For patients with reproductive potential must undergo counseling to understand unknown
risks to resultant progeny.
Exclusion Criteria:
- Diagnosis of immunodeficiency or active autoimmune condition.
- Active tuberculosis
- Prior exposure to PD-1 or PD-LI treatment
- Prior systemic chemotherapy within 2 weeks of planed anti-PD1 treatment.
- Received a live vaccine within 30 days of planned PD-1 start date.
- Pregnant or breastfeeding.
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Savanna Biedermann
650-721-4079
Not Recruiting