Education and Training
Swiss SOS MoCA - DCI Study
The primary objective of this multicenter observational study is to determine the effect size of the relationship between DCI and neuropsychological impairment 14-28 days and 3 months after aSAH.
Secondary objectives are the feasibility to administer and the validity of the MoCA in an intensive care unit setting, as well as the test/retest reliability of the MoCA in patients with acute brain damage in absence of aSAH.
Stanford is currently accepting patients for this trial.
Intervention(s):
- other: There is no intervention for this study. Patients are allocated to the study groups based on whether or not DCI occurs.
Eligibility
Inclusion Criteria:
For part 1 of the study:
Participants fulfilling all of the following inclusion criteria are eligible for the study:
- Consent of the patient or consent of patient's next of kin (plus consent of an
independent physician if patient is unable to consent)
- Aneurysmal SAH
- Age: ≥18
- Time of aSAH known (IMPORTANT: at least approximated. Time of aSAH refers to the bleed
that lead to hospital admission; warning leaks in the patient history are not
considered aSAH in this context)
- Complete aneurysm occlusion therapy within 48h after aSAH
- Glasgow coma scale (GCS) ≥ 13 points at time point 48h - 72h after aSAH
- Fluent language skills in either English, German, French, or Italian
For part 2 of the study:
Participants fulfilling all of the following inclusion criteria are eligible for the study:
- Consent of the patient or consent of patient's next of kin (plus consent of an
independent physician if patient is unable to consent)
- Age: ≥18
- Acute brain injury that requires a in-patient treatment, e.g. for (surgical) treatment
of a brain tumor, a cerebral hemorrhage, a hydrocephalus, stroke, or traumatic brain
injury, with stable neurological and general health status
- Glasgow coma scale (GCS) ≥ 13 points
- Fluent language skills in either English, German, French, or Italian
Exclusion Criteria:
For part 1 of the study:
The presence of any one of the following exclusion criteria will lead to exclusion of the
participant:
- SAH due to any other cause than aneurysm or structural abnormality of the brain
(arterio-venous malformation, dural arterio-venous fistula, cavernous malformation,
dissection, tumor, trauma)
- Comatose patients or patients with a reduced vigilance of GCS < 13 at time point 48h -
72h after aSAH
- No aneurysm occlusion therapy within 48h after aSAH
- Clear signs of arterial vasospasm in the initial (CT-)angiography; indicating that
aSAH had occurred already several days prior to admission
- Neurologic or psychiatric diseases other than aSAH that can potentially influence the
test-performance of a patient on the MoCA (e.g., dementia, multiple sclerosis, bipolar
disorder)
- Foreseeable difficulties in follow-up due to geographic reasons (e.g., patients living
abroad)
- Patients who are not fluent in English, German, French, or Italian
- Patients requiring sedative or other medication that would interfere with the
neuropsychological evaluation
For part 2 of the study:
The presence of any one of the following exclusion criteria will lead to exclusion of the
participant:
- Instable neurological or general health-status of the patient, that makes a transport
of the patient on the ICU or the office for neuropsychological testing impossible
- Suspected fluctuation of the neurological condition and the vigilance of the patient
between first and second testing
- Known psychiatric disease that can potentially influence the test-performance on the
MoCA (e.g., dementia, bipolar disorder)
- Patients who are not fluent in English, German, French, or Italian
- Patients requiring sedative or other medication that would interfere with the
neuropsychological evaluation
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Recruiting