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Perioperative Oral Steroids for Chronic Rhinosinusitis Without Polyps (CRSsNP)

While oral steroids have been shown to be effective in the management of patients with chronic rhinosinusitis with polyps, its role in treating chronic rhinosinusitis without polyps (CRSsNP) is ambiguous. Despite a lack of strong clinical evidence to suggest a benefit in this disease state, steroids are often prescribed as a component of post-operative care after sinus surgery for patients without polyps. Oral steroids carry with them significant adverse effects, and should be prescribed thoughtfully. The aims of this study are to determine if oral steroids in the peri-operative period improves patient outcomes in CRS without polyps.

Stanford is currently not accepting patients for this trial.

Stanford Investigator(s):

Intervention(s):

  • drug: Prednisone
  • drug: Flonase

Eligibility


Inclusion Criteria:

   - CRSsNP as defined by Clinical Practice Guideline (Update) on Adult Sinusitis

   - scheduled to undergo endoscopic sinus surgery

Exclusion Criteria:

   - chronic rhinosinusitis with polyps (CRSwNP)

   - Aspirin exacerbated respiratory disease

   - Cystic fibrosis

   - Immunosuppressive states (Human immunodeficiency virus, transplant)

   - Oral steroid use within 30 days of surgery

Ages Eligible for Study

18 Years - N/A

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Peter H Hwang, M.D.
650-725-6500
Not Recruiting