Education and Training

Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome

The investigators are testing treatment with low-dose naltrexone (LDN) for symptom relief of complex regional pain syndrome (CRPS). Study participants will be randomly assigned to receive either LDN or placebo for a period of several weeks. During this period participants will be asked to attend either in-person or virtual study visits and complete questionnaires.

Stanford is currently accepting patients for this trial.

Stanford Investigator(s):

Intervention(s):

  • drug: LDN
  • drug: Placebo

Eligibility


Inclusion Criteria:

   - Upper and/or lower extremity CRPS

   - On stable treatment for 1 month

   - CRPS for at least 1 year

   - Meet the Budapest criteria for CRPS at time of the study.

Exclusion Criteria:

   - Any known allergy to naltrexone or naloxone

   - Use of prescription opioid analgesics or illegal opioid use

   - Current or planned pregnancy.

Ages Eligible for Study

18 Years - 70 Years

Genders Eligible for Study

All

Now accepting new patients

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Birute Gedrimaite
650-497-0485
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