Education and Training
"A Long-Term Safety Study of JZP-110 in the Treatment of Excessive Sleepiness in Subjects With Narcolepsy or OSA"
This is a Phase 3 study to assess the long-term safety and maintenance of efficacy of JZP-110 in subjects who have completed Study 14-002, 14-003, 14-004, 15-004, 15-005, ADX-N05 201, or ADX-N05 202.
Stanford is currently accepting patients for this trial.
Intervention(s):
- drug: JZP-110
Eligibility
Major Inclusion Criteria:
1. Subject meets one of the following:
1. Completed Study 14-002 or 14-003 (Group A)
2. Completed Study 14-004, 15-004, 15-005, ADX-N05 201 or ADX-N05 202 (Group B)
2. Body mass index from 18 to <45 kg/m2
3. Consent to use a medically acceptable method of contraception
4. Willing and able to provide written informed consent
Major Exclusion Criteria:
1. Female subjects who are pregnant, nursing, or lactating
2. Any other clinically relevant medical, behavioral, or psychiatric disorder other than
narcolepsy or OSA that is associated with excessive sleepiness
3. History or presence of bipolar disorder, bipolar related disorders, schizophrenia,
schizophrenia spectrum disorders, or other psychotic disorders according to DSM-5
criteria
4. Presence of any acutely unstable medical condition, behavioral or psychiatric disorder
(including active suicidal ideation), or surgical history that could affect the safety
of the subject or interfere with study efficacy or safety assessments, or the ability
of the subject to complete the trial per the judgment of the Investigator
5. History of bariatric surgery within the past year or a history of roux-en-y procedure
6. Presence or history of significant cardiovascular disease
7. Use of any over the counter (OTC) or prescription medications that could affect the
evaluation of excessive sleepiness
8. Received an investigational drug other than JZP-110 in the past 30 days or five
half-lives (whichever is longer)
9. History of phenylketonuria (PKU) or history of hypersensitivity to
phenylalanine-derived products
Ages Eligible for Study
18 Years - 75 Years
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Recruiting