Education and Training
Combination Study of Urelumab and Cetuximab in Patients With Advanced/Metastatic Colorectal Cancer or Advanced/Metastatic Head and Neck Cancer
The purpose of the study is to determine the safety, tolerability and maximum tolerated dose of Urelumab in combination with Cetuximab in patients with Advanced/Metastatic Colorectal Cancer or Advanced/Metastatic Squamous Cell Carcinoma of the Head and Neck.
Stanford is currently not accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- biological: Urelumab
- biological: Cetuximab
Eligibility
For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com
Inclusion Criteria:
- Subjects with advanced/metastatic Colorectal Cancer(CRC) who have failed or been
intolerant to both irinotecan- and oxaliplatin- based regimens
- Subjects with advanced/metastatic Squamous cell carcinoma of the head and neck (SCCHN)
who are without options for curative treatment
- Subjects must have measurable disease per Response Evaluation Criteria in Solid Tumors
(RECIST) 1.1 criteria
- Men and women 18 and older
- Women of childbearing potential (WOCBP) and men must use highly effective methods of
contraception
- Eastern Cooperative Oncology Group (ECOG) of 0 or 1
- Subjects must have a life expectancy of at least 3 months
Exclusion Criteria:
- Active or progressing brain metastases
- Other concomitant malignancies (with some exceptions per protocol)
- Nasopharyngeal carcinoma
- Active or history of autoimmune disease
- Positive test for Human Immunodeficiency Virus (HIV) 1&2 or known AIDS
- History of any hepatitis (A,B or C)
- Known current drug or alcohol abuse
- Active Tuberculosis (TB)
- Use of anti-cancer treatments within 28 days
- Prior therapy with anti-CD137 antibody
Other protocol defined inclusion/exclusion criteria could apply
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
CCTO
650-498-7061
Not Recruiting