Inclusion Criteria:

   - Adult patients, >/= 18 years of age

   - Systemic sclerosis, as defined by American College of Rheumatology (1980) criteria

   - Disease duration of    manifestation)

   - >/= 15 and
   - Active disease, as defined by protocol

   - Uninvolved skin at injection sites

   - Negative pregnancy test for a female subject of childbearing potential

Exclusion Criteria:

   - Major surgery (including joint surgery) within 8 weeks prior to and/or during study
   enrollment

   - Rheumatic autoimmune disease other than systemic sclerosis

   - Skin thickening (scleroderma) limited to areas distal to the elbows or knees at
   screening

   - Previous treatment with tocilizumab

   - History of severe allergic or anaphylactic reactions to human, humanized, or murine
   monoclonal antibodies

   - Severe cardiopulmonary disease

   - Known active current or history of recurrent infections

   - Use of any investigational, biologic, or immunosuppressive therapies including
   intra-articular or parenteral corticosteroids prior to study enrollment as specified
   in the protocol

   - As specified in the protocol, any current or past medical condition or medical history
   involving but not limited to the nervous, renal, pulmonary, endocrine, and
   gastrointestinal organ systems determined by the Principal Investigator to pose a
   significant safety risk to any subject while participating in the study

   - Primary or secondary immunodeficiency