Education and Training

Early Intervention for Youth at Risk for Bipolar Disorder

Children or teens with mood swings or depression who have a parent with bipolar disorder are at high risk for developing bipolar disorder themselves. This study will test a family-based therapy aimed at preventing or reducing the early symptoms of bipolar disorder in high-risk children (ages 9-17). In a randomized trial, the investigators will compare two kinds of family-based treatment (one more and one less intensive) on the course of early mood symptoms and social functioning among high-risk children followed for up to 4 years. The investigators will examine the effects of family treatment on measures of neural activation using functional magnetic resonance imaging.

Stanford is currently not accepting patients for this trial.

Intervention(s):

  • behavioral: Enhanced Care
  • behavioral: Family-Focused Treatment
  • behavioral: Enhanced Care
  • behavioral: Family-Focused Treatment

Eligibility


Inclusion Criteria:

   - For a child to be eligible:

      - At least one biological parent or stepparent with whom the child or adolescent
      lives must be willing to participate in family treatment

      - At least one biological parent has a verifiable diagnosis of bipolar disorder I
      or II

      - The child must have a DSM-IV diagnosis of bipolar disorder not otherwise
      specified or major depressive disorder (MDD)

      - If the main diagnosis is MDD, the depressive episode must have occurred within
      the past 2 years

      - The child must have evidence of current significant affective symptoms, as
      determined by a score greater than 11 on the Young Mania Rating Scale within the
      last week or a score greater than 29 on the Child Depression Rating Scale-Revised
      within the last 2 weeks

      - The family must speak English, although English need not be their first language

Exclusion Criteria:

   - Fully diagnosable bipolar disorder I or II

   - Diagnosis of autism or pervasive developmental disorder

   - Evidence of mental retardation, as defined by an intelligence quotient (IQ) less than
   70

   - Presence of comorbid neurologic diseases such as seizure disorder

   - Substance or alcohol abuse or dependence disorders in the 4 months prior to study
   recruitment

   - Evidence of a life-threatening eating disorder or other medical disorder that requires
   emergency medical treatment

   - Currently enrolled in regular family therapy

   - Evidence of current sexual or physical abuse or domestic abuse between the adult
   partners

Ages Eligible for Study

9 Years - 17 Years

Genders Eligible for Study

All

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Kiki D Chang, MD
650-725-0956
Not Recruiting