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Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids

This research study explores whether a beta-blocker (propranolol) can prevent a person from becoming more sensitive to pain after administration of an opioid (remifentanil). Beta blockers inhibit the sympathetic (fight or flight) response and are often used to treat angina and high blood pressure. In a previous study in human volunteers, the investigators demonstrated an increased sensitivity to pain after a 60-minute infusion of the opioid remifentanil. The goal of this study is to identify a possible inhibitor of this phenomenon.

Stanford is currently not accepting patients for this trial.

Stanford Investigator(s):

Intervention(s):

  • drug: Placebo to Match Propranolol
  • drug: Remifentanil
  • drug: Propranolol

Eligibility


Inclusion Criteria:

   1. Healthy men,

   2. Age between 18 and 45 years

   3. Normal weight (according to the table provided by Metropolitan Life Insurance).

Exclusion Criteria:

   1. Hypersensitivity to opioids or naloxone,

   2. History of addictive disease,

   3. Significant cardiac, respiratory, gastrointestinal, neurological, dermatological, and
   psychiatric diseases,

   4. Concurrent medication with an analgesic drug,

   5. Student and employees affiliated with our laboratory

Ages Eligible for Study

18 Years - 45 Years

Genders Eligible for Study

Male

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Larry Chu, MD, MS
650-723-5439
Not Recruiting