Education and Training
Imaging and Biomarkers of Hypoxia in Solid Tumors
Hypoxia, meaning a lack of oxygen, has been associated strongly with a wide range of human cancers. Hypoxia occurs when tumor growth exceeds the ability of blood vessels to supply the tumor with oxygenated blood. It is currently understood that hypoxic tumors are more aggressive. Current methods for measuring hypoxia include invasive procedures such as tissue biopsy, or insertion of an electrode into the tumor. EF5-PET may be a non-invasive way to measure tumor hypoxia.
Stanford is currently not accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: EF5
- drug: Carbogen
- procedure: PET Scan
- drug: Dichloroacetate
Eligibility
INCLUSION CRITERIA
- Any solid tumor malignancies of any stage meeting all of the following criteria:
Minimum tumor dimension is at least 1 cm (to ensure it is above the detection
threshold of PET imaging). Examples include but are not limited to: locally advanced
squamous cell carcinoma of the head and neck to be treated by either initial surgery
or primary chemoradiotherapy; inoperable non-small cell lung cancer or pancreatic
carcinoma to be treated with stereotactic radiotherapy, which may be biopsied again at
the time of percutaneous needle delivery of implanted fiducial markers.
- Patients with newly diagnosed malignancies should not have initiated treatment for
their disease before participating in this study. Patients with recurrent or second
malignancies may have had prior therapy as appropriate for their disease, but should
have completed all prior treatment at least 30 days before participation in this study
and should not have initiated new treatment for the current problem.
- Greater than or equal to eighteen years of age.
- Sufficiently healthy to tolerate all study procedures.
- Organ and marrow function sufficient to undergo planned therapy.
- Ability to understand and the willingness to sign a written informed consent document.
EXCLUSION CRITERIA
• Pregnant or nursing
Ages Eligible for Study
18 Years - N/A
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
CCTO
650-498-7061
Not Recruiting