Inclusion Criteria:1) Age 18-60 2) Skin type II or III according to classification of
Fitzpatrick 3) Negative pregnancy test (women of childbearing potential) 4) Willing and
able to sign an informed consent form and Health Insurance Portability and Accountability
Act (HIPAA) authorization and to comply with study procedures

Exclusion Criteria:1) History of acute or chronic illness that may hinder study procedures
or confuse interpretation of the data (e.g. dermatological, neurological, psychiatric or
addictive diseases) 2) Clinically significant cardiovascular, pulmonary, hepatic or renal
diseases 3) Major bodily injury within 3 months of study participation 4) Surgery within 3
months of study participation 5) Pregnancy or breast-feeding 6) Intake of prescription
drugs with anti/pro-inflammatory action 7) Intake of prescription drugs with
anti/pro-analgesic action 8) Inability to abstain from any anti/pro inflammatory drugs
during the 24-hour period preceding a study session 9) Inability to abstain from any
anti/pro-analgesic drugs during the 24-hour period preceding a study session 10) Prior
medical history that would contraindicate the use of NSAID, or previous negative reaction
to NSAIDs or aspirin 11) Inability to obtain at least 6 hours of sleep during the night
preceding a study session