Education and Training
Theta-burst Transcranial Magnetic Stimulation
Theta-burst transcranial magnetic stimulation (TBS) is a type of repetitive transcranial magnetic stimulation (rTMS) method that reduces the excitability of a small region of brain for less than one hour. Since dystonia and spasticity may be associated with increased excitability of motor cortex, we expect that by reducing the excitability of motor cortex with TBS we will temporarily improve these symptoms and hopefully open avenues in the future for the use of TBS as a new, non-invasive therapeutic intervention to aid in physical therapy and symptom amelioration of dystonia and spasticity. We will test for motor improvement during the hour immediately following TBS using tests of muscle function and quality of limb movement.
Stanford is currently accepting patients for this trial.
Intervention(s):
- device: Transcranial magnetic stimulation
Eligibility
Inclusion Criteria:1. Dystonia affecting one or both hands or arms, and/or spasticity
affecting one or both hands/arms 2. Age 2 years to 29 years 3. Sufficient cognitive
function to attempt isolated finger movements Exclusion Criteria:1. any metallic implants
in the head or neck 2. seizure within 2 years of study entry, or prior history of status
epilepticus outside the newborn period.
3. deep-brain stimulator, vagal nerve stimulator, pacemaker, intrathecal baclofen pump, or
other implanted electrical device.
4. prior neurosurgical procedure 5. migraine disorder 6. known cardiac arrhythmia, or
history of syncope 7. use of tricyclic antidepressants or neuroleptic medications during
the study 8. use or requirement for medications to treat seizures
Ages Eligible for Study
2 Years - 29 Years
Genders Eligible for Study
All
Now accepting new patients
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Terence D Sanger, MD, PhD
(650) 736-2154
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