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Palonosetron and Hydroxyzine to Reduce Opioid Withdrawal

Opioid medications are commonly used for pain relief. When given over time, physical dependence can occur. This results in unpleasant side effects--such as agitation and nausea--if opioid medications are suddenly stopped. We are interested in knowing if a medication named Ondansetron can help ease or prevent symptoms associated with opioid withdrawal. We are also interested in knowing if a similar (but more potent FDA-approved drug, palonosetron) can more effectively treat withdrawal symptoms with or without combination with an antihistamine called hydroxyzine (vistaril).

Stanford is currently not accepting patients for this trial.

Stanford Investigator(s):

Intervention(s):

  • drug: palonosetron
  • drug: hydroxyzine
  • other: Placebo

Eligibility


Inclusion Criteria:

   - Healthy males

   - Ages 18-35

   - No allergies to morphine or palonosetron

   - No history of addiction or substance abuse

Exclusion Criteria:

   - Female

   - Younger than 18 or older than 35

   - History of substance abuse

   - Raynaud's disease or coronary artery disease

   - Allergies to morphine or palonosetron

Ages Eligible for Study

18 Years - 35 Years

Genders Eligible for Study

Male

Not currently accepting new patients for this trial

Contact Information

Stanford University
School of Medicine
300 Pasteur Drive
Stanford, CA 94305
Not Recruiting