Education and Training
A Study of R1507 in Participants With Recurrent or Refractory Sarcoma
The study was primarily designed to determine objective response, progression-free survival (PFS), and the safety and tolerability of R1507 in participants with recurrent or refractory Ewing's sarcoma, osteosarcoma, synovial sarcoma, rhabdomyosarcoma and other sarcomas including alveolar soft part sarcoma, desmoplastic small round cell tumor, extraskeletal myxoid chondrosarcoma, clear cell sarcoma, and myxoid liposarcoma.
Stanford is currently not accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: RG1507
Eligibility
Inclusion Criteria:
- progressive, recurrent or refractory Ewing's sarcoma, or recurrent or refractory
osteosarcoma, synovial sarcoma, rhabdomyosarcoma, or other sarcomas of the following
sub-types: alveolar soft part sarcoma, desmoplastic small round cell tumor,
extraskeletal myxoid chondrosarcoma, clear cell sarcoma and myxoid liposarcoma;
- Cohort 3 only: age must be >= 2 and <= 21 years
Exclusion Criteria:
- clinically significant unrelated systemic illness which would compromise the
participant's ability to tolerate the investigational agent, or interfere with the
study procedures or results;
- known hypersensitivity to any of the components of R1507 or prior hypersensitivity
reactions to monoclonal antibodies;
- treatment (within the past 2 weeks) with pharmacologic doses of corticosteroids or
other immunosuppressive agents;
- current or prior therapy with insulin-like growth factor (IGF) inhibitor (monoclonal
or specific kinase inhibitor);
- history of solid organ transplant;
- other malignant disease diagnosed within the previous 5 years, excluding
intra-epithelial cervical neoplasia or non-melanoma skin cancer;
- active central nervous system disease
Ages Eligible for Study
2 Years - N/A
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Maria Ahern
6507256413
Not Recruiting