Inclusion Criteria:Inclusion criteria for PMD (individuals with Psychotic Major Depression)
and NPMDs (individuals with Non-Psychotic Major Depression) are as follows:

   1. DSM IV diagnosis of Major Depressive Disorder with or without psychotic features,
   Bipolar II Disorder with or without psychotic features in a major depressive episode.

   2. 21-item HAM-D score greater than or equal to 21.

   3. Thase Core Endogenomorphic Scale score greater than or equal to 6 on the items
   included in the 21-item HDRS.

   4. Between 21 - 85 years of age.

   5. If currently taking antipsychotic, antidepressant, anticonvulsant, and/or
   mood-stabilizing medications, must be stable on the medication for at least one-week
   prior to entering the study.

   6. Pre-existing (current) primary treating psychiatrist for subjects with psychotic
   features.

   7. Any secondary diagnoses from the anxiety disorder spectrum is acceptable. Primary
   pre-existing chronic Obsessive-Compulsive Disorder(OCD) will be an exclusion criteria.

Inclusion criteria for healthy controls are as follows:

1. Between 21 - 85 years of age. 2. Taking no medications 3. Have a HAM-D score of less
than or equal to 5. Exclusion Criteria:Exclusion criteria for PMDs and NPMDs are as
follows:

   1. ECT in the 4 months prior to the study.

   2. Abuse of drugs or alcohol in the 6 months prior to study.

   3. Unstable or untreated hypertension, or cardiovascular disease.

   4. If participating in the blood draw portion of the protocol, endocrine disorders are
   exclusionary.

   5. Use of additional prescription medications, street drugs, or alcohol during the week
   before the study.

   6. Any Axis II diagnosis or traits which would make participation in the study difficult.

   7. Current pregnancy or lactation.

Exclusion criteria for healthy controls:

   1. Personal history of Axis I or Axis II disorders.

   2. Active unstable medical problems.

   3. Abuse of drugs or alcohol in the 6 months prior to study.

   4. Use of additional prescription medications, street drugs, or alcohol during the week
   before the study.

   5. Currently pregnant or lactating.