Inclusion Criteria:

   - Age >= 18 years of age

   - Histologically documented breast cancer (hormone receptor (ER/PR) status may be either
   positive or negative) with or without metastatic disease.

   - HER-2(+) as determined by one of the following measurements. NOTE: HER-2(+) assessment
   may have been on initial diagnosis and need not be repeated for metastatic lesions

      - Immunohistochemistry (IHC) 3+, or

      - FISH + (HER-2 gene signal to centromere 17 signal >2)

   - No transfusion dependent patients and no transfusion within 30 days of leukopheresis

   - Documented labs within 7 days of donation consisting of:

      - WBC > 4.0 K/ul & < 11.0 K/ul

      - platelet count > 150,000/mm3

      - hemoglobin > 11.0 g/dl.

      - Hematocrit > 33 %

   - Weight > 110 lbs

   - No blood donation in last 8 weeks (blood samples taken for standard of care less then
   30 cc/week are acceptable)

   - Patients must not have active or unresolved infection.

   - No cold or flu sympton at time of donation

   - No prior myocardial infarction or active cardiac disease (e.g. congestive heart
   failure, clinically significant cardiac valvular disease or arrhythmia requiring
   medications, angina pectoris, uncontrolled hypertension, clinically significant
   pericardial effusion)

   - All patients must give signed written informed consent.

   - ECOG Performance Score of 0 or 1.

   - Women of childbearing potential must have a negative serum or urine pregnancy test

Exclusion Criteria:

   - The presence of another active malignancy

   - Pregnant, lactating, or nursing

   - Patients with prior myocardial infarction or active cardiac disease (e.g. congestive
   heart failure, clinically significant cardiac valvular disease or arrhythmia requiring
   medications, angina pectoris, uncontrolled hypertension, clinically significant
   pericardial effusion)