Education and Training
Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients
The purpose of this chart review study is to determine whether the use of dexmedetomidine, a selective α2-adrenergic receptor agonist with sedative, analgesic, and antinociceptive properties, would be associated with a lower incidence of delirium when compared to propofol and midazolam. We hypothesize that sedation with dexmedetomidine following cardiac surgery with CPB will be associated with a lower incidence of postoperative delirium.
Stanford is currently not accepting patients for this trial.
Stanford Investigator(s):
Intervention(s):
- drug: dexmedetomidine
- drug: midazolam
- drug: propofol
Eligibility
Inclusion Criteria:
1. Diagnosis of a coronary artery disease, cardiac valve disease, or vascular problems
requiring elective surgical intervention
2. Age older than 18 years of age, less than 90 years of age
3. Fluency in English, and willingness to participate in the study
4. No history of recent (< 3 months) of alcohol or drug abuse
5. No pre-operative evidence of heart block
6. No history of dementia, schizophrenia, or post-traumatic stress disorder
Exclusion Criteria:
1. A preexisting diagnoses of dementia, schizophrenia, active or recent alcohol or drug
abuse/dependence; post-traumatic stress disorder; acute intoxication (i.e., positive
urine drug and/or alcohol test at the time of initial evaluation or upon
hospitalization for surgery)
2. Age younger than 18, or older than 89 years of age
3. Inability to understand enough English to complete required diagnostic testing
4. Unwillingness to participate in the study
5. Inability of subject or surrogate to consent.
6. Pregnancy
Ages Eligible for Study
18 Years - 89 Years
Genders Eligible for Study
All
Not currently accepting new patients for this trial
Contact Information
Stanford University
School of Medicine
300 Pasteur Drive
Stanford,
CA
94305
Not Recruiting