Stanford School of Medicine
Radiation Oncology–

Kang-Hyun Ahn


Ph.D. in Medical Physics,
University of Chicago, Chicago, IL, 2006

Research

My doctoral research addressed electron paramagnetic resonance imaging (EPRI). Unpaired electrons under the resonance condition generate spectra that quantify crucial parameters relevant to physiological application. Specifically, collisions of the paramagnetic molecules produce an exchange of spin states, which leads to a linear line broadening proportional to oxygen concentration. 3D spatial, 1D spectral EPRI provides high resolution images of tumor and tissue oxygenation aimed at oxygen image guided radiation therapy. I improved the image quality using various techniques that exploit the unique characteristics of EPRI, and carried out animal experiments to validate EPRI for the study of tumor oxygenation. Currently my work involves development of multimodality parametric imaging for adaptive radiation therapy.


Publications

  1. Ahn K, Subramanian VS, and Halpern HJ, Scaling of EPR spectral-spatial images with size of sample: images of a sample greater than 5 cm in linear dimension. Med Phys, 2007 submitted.
  2. Kao JPY, Barth ED, Burks SR, Smithback P, Mailer C, Ahn K, Halpern HJ, and Rosen GM, Very-Low-Frequency EPR Imaging of Nitroxide-loaded Cells, Magn Reson Med, 2007 in press.
  3. Ahn K, Halpern HJ, Simulation of 4D spectral-spatial EPR images. J Magn Reson, 2007, 187, p.1-9.
  4. Ahn K, Halpern HJ, Object dependent sweep width reduction with spectral-spatial EPR imaging. J Magn Reson, 2007, 186, p.105-111.
  5. Ahn K, Halpern HJ, Comparison of local and global angular interpolation applied to spectral-spatial EPR image reconstruction. Med Phys, 2007, 34(3), p.1047-1052.
  6. Ahn K, Halpern HJ, Spatially uniform sampling in 4D spectral-spatial imaging. J Magn Reson, 2007, 185, p.152-158.
  7. Elas M*, Ahn K*, Parasca A, Barth E, Lee D, Haney C, and Halpern HJ, Electron paramagnetic resonance oxygen images correlate spatially and quantitatively with Oxylite oxygen measurements. Clin Cancer Res, 2006. 12(14 Pt 1): p.4209-4217.

* Equal contributors to this work

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