Attardi Lab
Defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches.

J. Martin Brown Lab
Improving cancer therapy by exploiting the hypoxia and presence of necrosis in solid tumors and finding new cancer susceptibility genes using the power of yeast genomics.

Denko Lab
Tumor biology, especially the effects of the tumor microenvironment (such as hypoxia), hypoxic gene regulation, hypoxia effector genes, apoptosis.

Giaccia Lab
Cellular response to hypoxia and ionizing radiation; cell-cycle control, apoptosis and angiogenesis in transformed cells

Affiliated Laboratories

Lab	Department	Research Emphasis
Knox	Radiation Oncology	Bcl-2, Apoptotic signaling pathways (membrane and mitochondrial-mediated events), Development of novel therapeutic strategies to sensitize tumor cells to cytotoxic therapies, Cox-2, NF-kB, Anti-angiogenesis therapies
Koong	Radiation Oncology	Mechanisms of gene transcription and protein translation under hypoxic conditions
Le	Radiation Oncology	Identification of serum markers for tumor hypoxia and for prognosis in patients with head and neck or lung cancers